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	<title>ROS - Revision history</title>
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	<updated>2026-10-17T07:25:55Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wiki.beaconcancer.org/index.php?title=ROS&amp;diff=21975&amp;oldid=prev</id>
		<title>Victor at 00:33, 27 August 2024</title>
		<link rel="alternate" type="text/html" href="https://wiki.beaconcancer.org/index.php?title=ROS&amp;diff=21975&amp;oldid=prev"/>
		<updated>2024-08-27T00:33:36Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 00:33, 27 August 2024&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;ROS1 is a gene that encodes a receptor tyrosine kinase involved in cell growth and differentiation. Alterations in ROS1, such as gene fusions, are found in a subset of cancers, including non-small cell lung cancer and certain types of sarcomas. These fusions lead to the production of abnormal ROS1 proteins that drive uncontrolled cell proliferation and &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tumor &lt;/del&gt;growth. Identifying ROS1 gene fusions in &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tumors &lt;/del&gt;is crucial for guiding treatment decisions, as targeted therapies, specifically ROS1 inhibitors, can effectively block the activity of these aberrant proteins. These inhibitors have shown promising results in reducing &lt;del style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tumor &lt;/del&gt;size and improving patient outcomes. Understanding ROS1&amp;#039;s role in cancer allows for personalized treatment strategies, providing more effective and tailored therapeutic options for patients with ROS1-positive cancers.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;ROS1 is a gene that encodes a receptor tyrosine kinase involved in cell growth and differentiation. Alterations in ROS1, such as gene fusions, are found in a subset of cancers, including non-small cell lung cancer and certain types of sarcomas. These fusions lead to the production of abnormal ROS1 proteins that drive uncontrolled cell proliferation and &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tumour &lt;/ins&gt;growth. Identifying ROS1 gene fusions in &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tumours &lt;/ins&gt;is crucial for guiding treatment decisions, as targeted therapies, specifically ROS1 inhibitors, can effectively block the activity of these aberrant proteins. These inhibitors have shown promising results in reducing &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;tumour &lt;/ins&gt;size and improving patient outcomes. Understanding ROS1&amp;#039;s role in cancer allows for personalized treatment strategies, providing more effective and tailored therapeutic options for patients with ROS1-positive cancers.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Victor</name></author>
	</entry>
	<entry>
		<id>https://wiki.beaconcancer.org/index.php?title=ROS&amp;diff=18056&amp;oldid=prev</id>
		<title>Victor: Created page with &quot;ROS1 is a gene that encodes a receptor tyrosine kinase involved in cell growth and differentiation. Alterations in ROS1, such as gene fusions, are found in a subset of cancers, including non-small cell lung cancer and certain types of sarcomas. These fusions lead to the production of abnormal ROS1 proteins that drive uncontrolled cell proliferation and tumor growth. Identifying ROS1 gene fusions in tumors is crucial for guiding treatment decisions, as targeted therapies,...&quot;</title>
		<link rel="alternate" type="text/html" href="https://wiki.beaconcancer.org/index.php?title=ROS&amp;diff=18056&amp;oldid=prev"/>
		<updated>2024-05-21T18:08:00Z</updated>

		<summary type="html">&lt;p&gt;Created page with &amp;quot;ROS1 is a gene that encodes a receptor tyrosine kinase involved in cell growth and differentiation. Alterations in ROS1, such as gene fusions, are found in a subset of cancers, including non-small cell lung cancer and certain types of sarcomas. These fusions lead to the production of abnormal ROS1 proteins that drive uncontrolled cell proliferation and tumor growth. Identifying ROS1 gene fusions in tumors is crucial for guiding treatment decisions, as targeted therapies,...&amp;quot;&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;ROS1 is a gene that encodes a receptor tyrosine kinase involved in cell growth and differentiation. Alterations in ROS1, such as gene fusions, are found in a subset of cancers, including non-small cell lung cancer and certain types of sarcomas. These fusions lead to the production of abnormal ROS1 proteins that drive uncontrolled cell proliferation and tumor growth. Identifying ROS1 gene fusions in tumors is crucial for guiding treatment decisions, as targeted therapies, specifically ROS1 inhibitors, can effectively block the activity of these aberrant proteins. These inhibitors have shown promising results in reducing tumor size and improving patient outcomes. Understanding ROS1&amp;#039;s role in cancer allows for personalized treatment strategies, providing more effective and tailored therapeutic options for patients with ROS1-positive cancers.&lt;/div&gt;</summary>
		<author><name>Victor</name></author>
	</entry>
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