Comparative Genomic Hybridization (CGH)

Comparative Genomic Hybridization (CGH) is a sophisticated molecular technique used to detect and analyze genetic variations and abnormalities within a genome. By comparing a patient's DNA sample to a reference genome, CGH can identify gains or losses of DNA segments, which may indicate conditions such as cancer or genetic disorders. This method involves labeling DNA from both samples with different fluorescent dyes, allowing researchers to visualize and quantify the differences when the samples are hybridized on a microarray or chromosome slide. CGH provides detailed insights into genetic alterations, aiding in the diagnosis and personalized treatment of various diseases. This non-invasive and highly precise technique is pivotal in advancing our understanding of genetics and improving patient care.