Editing Data Dictionary: ZfkD Cancer Registry (Germany)

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{| class="wikitable"
! Variable (English) !! Description !! Value range
|-
| Date of birth || Patient's date of birth represented in international format YYYY-MM-DD.  || Date YYYY-MM-DD
|-
| Date of death or last known alive date || Date of death (imputed) or last known alive date. For DCO cases, date of death = incidence date. || Date YYYY-MM-DD
|-
| Other cause of death, ICD-10 code || Other cause(s) of death as reported to the registry, ICD-10 code || ICD-10 code
|-
| Other cause of death, ICD-10 version || ICD-10 version used to encode other cause(s) of death || ICD-10 version
|-
| Diagnosis date || Date of incidence represented in international format YYYY-MM-DD. For DCO cases, incidence date = date of death. || Date YYYY-MM-DD
|-
| Year of incidence || Year of incidence. For DCO cases, year of incidence is equal to year of death. || Date YYYY
|-
| Age at diagnosis || Number of years between date of birth and date of diagnosis || Age (years)
|-
| Place of residence at diagnosis || "Place of residence at diagnosis, represented by 5-digit area code (""Kreiskennziffer"")" || 5-digit area code
|-
| Place of residence at diagnosis || "Place of residence at diagnosis, represented by 2-digit area code (""Bundesland"")" || 2-digit area code
|-
| Tumour diagnosis, ICD-10 code || ICD-10 diagnostic code of tumour || ICD-10, 4-digit code
|-
| Tumour diagnosis, ICD-10 version || ICD-10 version used to encode tumour diagnosis || ICD-10 version
|-
| Topography of tumour, ICD-O-3 code || Tumour site represented by ICD-O-3 topography code || ICD-O-3 (topography section) 4-digit code
|-
| Morphology of tumour, ICD-O-3 code || Morphology and behavior of tumour represented by 5-digit ICD-O-3 code. The fifth digit indicates tumour behavior (/0 benign; /1 uncertain; /2 carcinoma in situ; /3 malignant). || ICD-O-3 (morphology section), 5-digit code
|-
| Number of lymph nodes examined || Number of lymph nodes that were examined for the presence of cancer cells || (n) = number of lymph nodes
|-
| Number of lymph nodes affected || Number of lymph nodes that contain cancer cells || (n) = number of lymph nodes
|-
| cTNM: T || Describes the size of the primary tumour. Staging according to tumour-specific TNM. || T stage, tumour-specific
|-
| cTNM: N || Describes the degree of spread to regional lymph nodes. Staging according to tumour-specific TNM. || N stage, tumour-specific
|-
| cTNM: UICC Stage || UICC Stage according to TNM. Describes the anatomical extent of disease. || UICC stage, tumour-specific
|-
| pTNM: T || Describes the size of the primary tumour. Staging according to tumour-specific TNM. || T stage, tumour-specific
|-
| pTNM: N || Describes the degree of spread to regional lymph nodes. Staging according to tumour-specific TNM. || N stage, tumour-specific
|-
| pTNM: UICC stage || UICC Stage according to TNM. Describes the anatomical extent of disease. || UICC stage, tumour-specific
|-
| Other classification system: name || Name and/or type of other classification(s) used || e.g. Ann Arbor staging, WHO Classification of CNS Tumours, AJCC
|-
| Other classification system: stage || Stage assigned based on other classification system || Stage
|-
| Survival time || Time interval between incidence date and death || (n) = number of days
|-
| Tumour size || Maximum diameter of invasive carcinoma (in mm) || (n) = tumour size in mm
|-
| DCIS size || Maximum diameter of ductal carcinoma in situ (in mm) || (n) = DCIS size in mm
|-
| PSA level || PSA level (ng/mL) || (n) = level in ng/mL
|-
| PSA level date || Date of PSA blood test || Date YYYY-MM-DD
|-
| Gleason: primary grade || Primary Gleason grade || 1, 2, 3, 4 or 5
|-
| Gleason: secondary grade || Secondary Gleason grade || 1, 2, 3, 4 or 5
|-
| Gleason score || Gleason score || 2, 3, 4, 5, 6, 7, 7a, 7b, 8, 9 or 10
|-
| Tumour thickness || Thickness of tumour (mm) || (n) = thickness in mm
|-
| LDH level || LDH level (units per liter) || (n) = level in U/L
|-
| Surgery date || Surgery date represented in ISO 8601 format YYYY-MM-DD. Year and month of surgery are collected from registries, day of surgery is assigned an arbitrary value. || Date YYYY-MM-DD
|-
| Surgery type || OPS code of surgery || OPS code
|-
| OPS version || OPS version used to encode surgery type || OPS version number
|-
| Time to surgery || Number of days between diagnosis and surgery || (n) = number of days
|-
| Radiotherapy start date || Radiotherapy start date || Date YYYY-MM-DD
|-
| Percutaneous radiotherapy - Stereotactic || Indicates if percutaneous radiotherapy (external beam radiotherapy) was applied using stereotactic techniques. || ST = stereotactic
|-
| Percutaneous radiotherapy - Respiratory-gated || Indicates if percutaneous radiotherapy (external beam radiotherapy) was respiratory-gated. || 4D = respiratory-gated
|-
| Radiotherapy duration || Number of days between diagnosis and surgery || (n) = number of days
|-
| Time to radiotherapy || Time interval between incidence date and radiotherapy start date (days) || (n) = number of days
|-
| Systemic therapy drug || Medication(s) used for systemic therapy. Multiple medications require separate entries. || Name or: ATC code + ATC version
|-
| Systemic therapy protocol type || Systemic therapy protocol name or code. || "Name or: protocol code
|-
| Systemic therapy protocol || Systemic therapy protocol code.  || Suggested guidance: https://plattform65c.atlassian.net/wiki/spaces/UMK/pages/15532519/Protokolle
|-
| Systemic therapy protocol || Systemic therapy protocol name  || (name) = protocol name
|-
| Systemic therapy protocol || Systemic therapy protocol version || (version) = protocol version
|-
| Systemic therapy start date || Systemic therapy start date || Date YYYY-MM-DD
|-
| Systemic therapy duration || Systemic therapy duration (days) || (n) = number of days
|-
| Time to systemic therapy || Time interval between incidence date and systemic therapy start date (days) || (n) = number of days
|-
| Follow-up date || Date of most recent follow-up evaluation of tumour status || Date YYYY-MM-DD
|-
| TNM: T || Describes the size of the primary tumour. Staging according to tumour-specific TNM. || T stage, tumour-specific
|-
| TNM: N || Describes the degree of spread to regional lymph nodes. Staging according to tumour-specific TNM. || N stage, tumour-specific
|-
| TNM: UICC stage || UICC Stage at follow-up according to TNM. Describes the anatomical extent of disease. || UICC stage, tumour-specific
|-
| Other classification system: name || Name and/or type of other classification(s) used || e.g. Ann Arbor staging, WHO Classification of CNS Tumours, AJCC
|-
| Other classification system: stage || Stage assigned based on other classification system || Stage
{| class="wikitable"
! Basis of diagnosis !! Describes how the tumour was identified !! "0 = death certificate only (DCO); 
|-
| 1 = clinical, ie physical exam only (no tumour-specific diagnostics);  ||  || 
|-
| 2 = clinical investigation using diagnostic techniques such as imaging, endoscopy, laparatomy, autopsy (no histopathology);  ||  || 
|-
| 4 = specific tumour markers;  ||  || 
|-
| 5 = cytology;  ||  || 
|-
| 6 = histopathology, metastasis;  ||  || 
|-
| 7 = histopathology, primary tumour;  ||  || 
|-
| 9 = unknown"  ||  || 
|-
| Tumour laterality || Describes which side of a paired organ is affected || "L = left; 
|-
| R = right;  ||  || 
|-
| B = bilateral;  ||  || 
|-
| M = center;  ||  || 
|-
| U = unknown;  ||  || 
|-
| T = not applicable (e.g., systemic disease)"  ||  || 
|-
| Death certificate notified (DCN) || Indicates whether or not the case was first notified by death certificate (official cause of death). || "J = Yes; 
|-
| N = No"  ||  || 
|-
| Survival time || Time interval between incidence date and death || (n) = number of days 
|-
| Tumour size || Maximum diameter of invasive carcinoma (in mm) || (n) = tumour size in mm 
|-
| DCIS size || Maximum diameter of ductal carcinoma in situ (in mm) || (n) = DCIS size in mm 
|-
| Menopausal status || Menopausal status before initiation of treatment. Postmenopausal = time since last menstruation > 1 year OR E2 and FSH within postmenopausal range. || "1 = premenopausal (includes perimenopausal); 
|-
| 3 = postmenopausal;  ||  || 
|-
| U = unknown"  ||  || 
|-
| Estrogen receptor status || Estrogen receptor status according to immunoreactivity score (IRS) || "P = positive (IRS >= 1); 
|-
| N = negative;  ||  || 
|-
| U = unknown"  ||  || 
|-
| Progesterone receptor status || Progesterone receptor status according to immunoreactivity score (IRS) || "P = positive (IRS >= 1); 
|-
| N = negative;  ||  || 
|-
| U = unknown"  ||  || 
|-
| HER2 status || HER2 (ERBB2) status || "P = positive (ICH+++ or: ICH++ and positive ISH); 
|-
| N = negative;  ||  || 
|-
| U = unknown"  ||  || 
|-
| PSA level || PSA level (ng/mL) || (n) = level in ng/mL 
|-
| PSA level date - accuracy || Indicates if only year is accurate (M), if year and month are accurate (T), or if year and month are estimated (V). Please note: Day is not collected from registries and assigned an arbitrary value (usu. 15) by ZfKD. || "M = year is accurate, month is estimated; 
|-
| T = year and month are accurate;  ||  || 
|-
| V = year and month are estimated"  ||  || 
|-
| PSA level date || Date of PSA blood test || Date YYYY-MM-DD 
|-
| Gleason: primary grade || Primary Gleason grade || 1, 2, 3, 4 or 5 
|-
| Gleason: secondary grade || Secondary Gleason grade || 1, 2, 3, 4 or 5 
|-
| Gleason score || Gleason score || 2, 3, 4, 5, 6, 7, 7a, 7b, 8, 9 or 10 
|-
| Gleason score: sampling method || Describes tissue sampling method/origin of tissue sample used to determine Gleason score. || "O = prostatectomy; 
|-
| S = punch biopsy;  ||  || 
|-
| U = unknown"  ||  || 
|-
| Tumour thickness || Thickness of tumour (mm) || (n) = thickness in mm 
|-
| Ulceration || Indicates whether or not ulceration is present. || "J = Yes; 
|-
| N = No"  ||  || 
|-
| LDH level || LDH level (units per liter) || (n) = level in U/L 
|-
| Position || Rectal carcinoma: Distance between anocutaneous line and aboral tumour margin (in cm) || "(n) = distance from anocutaneous line in cm; 
|-
| U = unknown"  ||  || 
|-
| KRAS mutation || Indicates presence of KRAS proto-oncogene mutations || "W = wild type; 
|-
| M = mutation;  ||  || 
|-
| U = unknown;  ||  || 
|-
| N = not assessed"  ||  || 
|-
| Surgery date - accuracy || Indicates if only year is accurate (M), if year and month are accurate (T), or if year and month are estimated (V). Please note: Day is not collected from registries and assigned an arbitrary value (usu. 15) by ZfKD. || "M = year is accurate, month is estimated; 
|-
| T = year and month are accurate;  ||  || 
|-
| V = year and month are estimated"  ||  || 
|-
| Surgery date || Surgery date represented in ISO 8601 format YYYY-MM-DD. Year and month of surgery are collected from registries, day of surgery is assigned an arbitrary value. || Date YYYY-MM-DD 
|-
| Surgery type || OPS code of surgery || OPS code 
|}