University Hospital for Tumours of Zagreb

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The University Hospital for Tumors of Zagreb is a tumor clinic that constantly monitors and implements new methods of tumor treatment, and carries out multiple research and teaching projects. It has been part of the Sestre Milosrdnice University Hospital Centre since 2010.

See other cancer centers in Croatia.

Trials

A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice (IMreal)

Summary: This is a non-interventional, multi-country, multi-centre, multiple cohort prospective study, with retrospective collection of prior medical/treatment history data from medical records, designed to assess the real-world outcomes and safety of atezolizumab for indications in the existing label in the real world setting of routine clinical practice.

Sponsor, manager, or home institution: Hoffmann-La Roche

Intervention/Treatment: Drug: Atezolizumab

Number of patients: 3400 participants

Beginning Date: December 20, 2018

Last Update: December 20, 2022

Recruitment Status: Recruiting.

Cancer areas of interest: Urothelial Carcinoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Hepatocellular Carcinoma

A Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC) (KATE3)

Summary: This study will evaluate the efficacy, safety and patient-reported outcomes of trastuzumab emtansine plus atezolizumab compared with trastuzumab emtansine plus placebo in participants with HER2-positive and PD-L1-positive LABC or MBC.Participants must have progressed either during or after prior trastuzumab- (+/- pertuzumab) and taxane-based therapy for LABC/MBC; or during (or within 6 months after completing) trastuzumab- (+/-pertuzumab) and taxane-based therapy in the neoadjuvant and/or adjuvant setting.

Sponsor, manager, or home institution: Hoffmann-La Roche

Intervention/Treatment: Drug: Trastuzumab Emtansine; Drug: Atezolizumab; Other: Placebo

Number of patients: 320 participants

Beginning Date: February 5, 2021

Last Update: December 14, 2022

Recruitment Status: Recruiting

Cancer areas of interest: Metastatic Breast Cancer

Experts

Department of Anesthesiology, Reanimatology and Intensive Treatment

Procedures: abdominal, gynecological, head and neck oncologic surgeries along with oncoplastic and reconstructive surgery.

Contact: https://www.kbcsm.hr/klinike/klinika-za-tumore/anesteziologija-reanimacija-i-intezivno-lijecenje/

Experts: https://www.kbcsm.hr/klinike/klinika-za-tumore/anesteziologija-reanimacija-i-intezivno-lijecenje/

Department of Head and Neck Surgery

Procedures: Works on squamous cell carcinomas of the upper aerodigestive system, salivary gland, skin cancers, melanomas of the head, neck and thyroid surgical treatments and plastic-reconstructive surgery combined with radiotherapy, chemotherapy and rehabilitation.

Contact: https://www.kbcsm.hr/klinike/klinika-za-tumore/zavod-za-kirusku-onkologiju/

Experts: https://www.kbcsm.hr/klinike/klinika-za-tumore/zavod-za-kirusku-onkologiju/

Department of gynecological-oncological surgery

Procedures: Acts on prevention and early diagnosis of gynecological tumors using modern medical equipment, performs consults, local radiation therapy, and surgeries with endoscopic, vaginal and laparotomic approaches.

Contact: https://www.kbcsm.hr/klinike/klinika-za-tumore/zavod-za-kirusku-onkologiju/odjel-za-ginekolosko-onkolosku-kirurgiju/

Experts: https://www.kbcsm.hr/klinike/klinika-za-tumore/zavod-za-kirusku-onkologiju/odjel-za-ginekolosko-onkolosku-kirurgiju/

Department of Oncological Pathology and Clinical Cytology

Procedures: Works with the methods of biopsy, immunohistochemical markers, chromogenic in situ hybridization (CISH), silver-stained in situ hybridization (SISH), and PCR analysis to examinate the received samples. Also acts on emergency cytology.

Contact: https://www.kbcsm.hr/klinike/klinika-za-tumore/onkoloska-patologija/

Experts: https://www.kbcsm.hr/klinike/klinika-za-tumore/onkoloska-patologija/

Department of Internal Oncology

Procedures: unknown

Contact: https://www.kbcsm.hr/zavod-za-internisticku-onkologiju/

Experts: https://www.kbcsm.hr/zavod-za-internisticku-onkologiju/

Department of Radiotherapy and Oncology

Procedures: unknown

Contact: https://www.kbcsm.hr/zavod-za-radioterapiju-i-onkologiju/

Experts: https://www.kbcsm.hr/zavod-za-radioterapiju-i-onkologiju/

Institute for Oncoplastic and Reconstructive Surgery

Procedures: unknown

Contact: https://www.kbcsm.hr/zavod-za-onkoplastiku-i-rekonstruktivnu-kirurgiju/

Experts: https://www.kbcsm.hr/zavod-za-onkoplastiku-i-rekonstruktivnu-kirurgiju/

Department of oncoplasty

Procedures: Diagnosis by USV of the breast and abdomen, mammography, MRI, cytopuncture, biopsy, X-ray processing, and sentinel node biopsy or axillary lymph node dissection. Cancer systemic treatments used are chemotherapy, immunotherapy, hormone therapy and radiation. Performs radical, reconstructive and sparing surgical procedures involved in surgical removal of tumors and assymmetry correction. Also acts on treatment of melanoma and soft tissue sarcomas

Contact: https://www.kbcsm.hr/klinike/klinika-za-tumore/zavod-za-kirusku-onkologiju/odjel-za-onkoplastiku/

Experts: https://www.kbcsm.hr/klinike/klinika-za-tumore/zavod-za-kirusku-onkologiju/odjel-za-onkoplastiku/

Learning Resources

Library of the University Hospital for Tumors

Content Type: Library containing publications from the field of oncology and other biomedical subjects such as surgery, radiology, anesthesia, otorhinolaryngology, internal medicine, radiotherapy, etc. The library can also be used to search medical databases, bibliometric services and certificates, and other information. Librarians can help with instructions on how to find relevant literature. There are currently about 1,722 printed books and about 14,000 volumes of magazines (130 titles).

Target Audience: Anyone in the region can access the library and create an account. The content is more relevant to providers and researchers.

Open Data Access: Library can be accessed here.