North Estonia Medical Centre
The North Estonia Medical Centre is one of the top healthcare providers in the country. Its statutes states that their goal is "to provide high-quality, specialized medical care and ambulance services, to be the learning base of training that precedes and follows the acquiring of health care professionals’ qualifications and does healthcare-related study and research work."
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Trials
Summary: This is a 2-part trial: a Phase 1, open-label, dose-escalation study in subjects with metastatic or locally advanced solid tumors, with a consecutive Phase 2 expansion to evaluate efficacy in subjects with recurrent, unresectable, or metastatic (advanced) cervical cancer that has progressed after a platinum-based treatment regimen.
Sponsor, manager, or home institution: Agenus Inc.
Intervention/Treatment: Drug: AGEN2034
Number of patients: 211 participants
Beginning Date: April 7, 2017
Last Update: November 3, 2022
Recruitment Status: Completed.
Cancer areas of interest: Advanced Cancer and Cervical Cancer
Summary: This study is designed to assess the antitumor efficacy and safety of pembrolizumab in combination with chemoradiotherapy (CRT) versus CRT alone in participants with muscle-invasive bladder cancer (MIBC). The primary hypothesis is that pembrolizumab + chemoradiotherapy is superior to placebo + chemoradiotherapy with respect to bladder intact event-free survival.
Sponsor, manager, or home institution: Merck Sharp & Dohme LLC
Intervention/Treatment: Drug: Pembrolizumab; Radiation: Conventional Radiotherapy (Bladder only); Radiation: Conventional Radiotherapy (Bladder and pelvic nodes); Radiation: Hypofractionated Radiotherapy (Bladder only); Drug: Cisplatin; Drug: Fluorouracil (5-FU); Drug: Mitomycin C (MMC); Drug: Gemcitabine; Drug: Placebo to Pembrolizumab
Number of patients: 636 participants
Beginning Date: January 27, 2020
Last Update: October 21, 2022
Recruitment Status: Recruiting.
Cancer areas of interest: Urinary Bladder Neoplasms
Experts
General and Oncology Urology Centre
Oncology and Haematology Policlinic
Learning Resources
Other Learning Materials
Association: Patient Advisory Council
Content Type: Ensures the interests of the patient are being taken into account when making decisions and designing services, and that the patient has an active role in the treatment process.
Members: Estonian Rheumatism Association; Avitus NGO; Estonian Inflammatory Bowel Disease Society NGO; Estonian Celiac Society; Estonian Psoriasis Association; Estonian Hemophilia Society;Estonian Chamber of Disabled People; Tallinn Chamber of Disabled People; Saaremaa Cancer Society; Läänemaa Cancer Association; Estonian Stroke Patients Society.
Access: Information [1]
Service: Tobacco Cessation Counseling Office
Content Type: Trained nurses perform counseling, organize a treatment plan for the patients, and accompany them during a specific time to help them quit smoking.
Target Audience: Free for everyone.
Access: Information [2]
Service: Chemotherapy Counseling
Content Type: A nurse-counselor instructs the patient and his family individually before, during, and after the chemotherapy treatment about the procedure, possible side effects, and how to deal with those.
Target Audience: Patients and their relatives.
Access: Information [3]
Service: Palliative Care Nurse Advisor
Content Type: A nurse instructs about the disease the patient is suffering from and how to deal with it and connects the patient to specialists who will help with palliative care.
Target Audience: Patients and their relatives.
Access: Information [4]
Resource: Learning Resources for Relatives and Caretakers
Content Type: Guides and counseling appointment information.
Target Audience: Patients, Relatives and Caretakers.
Access: Information [5]
