Trials (University Medical Center Groningen Comprehensive Cancer Center)
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NCTID: NCT03719690
Title: Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy Study Summary: An international, multicenter, open-label, 2 cohort, non-comparative, pivotal study evaluating the efficacy of tipifarnib in HRAS mutant HNSCC (AIM-HN). The first cohort will assess the objective response rate (ORR) of tipifarnib in subjects with HNSCC with HRAS mutations. The second study cohort, SEQ-HN, is an observational sub-study including HNSCC patients in whom HRAS mutations were not identified (wild type HRAS HNSCC) and who consent to provide first line outcome data and additional follow up. Sponsor: Kura Oncology, Inc. Intervention: Tipifarnib Start Date: 2018-11-05 Last Updated: 2022-11-09 Number of Patients: 284 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: HRAS Gene Mutation
NCTID: NCT00626990
Title: Phase III Trial of Anaplastic Glioma Without 1p/19q Loss of Heterozygosity (LOH) Study Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether giving temozolomide during and/or after radiation therapy is more effective than radiation therapy alone in treating anaplastic glioma. PURPOSE: This randomized phase III trial is studying giving temozolomide during and/or after radiation therapy to see how well it works compared to radiation therapy alone in treating patients with anaplastic glioma. Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Intervention: temozolomide Start Date: 2007-12 Last Updated: 2023-09-11 Number of Patients: 751 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Brain and Central Nervous System Tumors
NCTID: NCT05171075
Title: A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE Study Summary: This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal (GI)/genitourinary (GU) cancer associated VTE (Magnolia) Sponsor: Anthos Therapeutics, Inc. Intervention: Abelacimab Start Date: 2022-09-27 Last Updated: 2023-11-21 Number of Patients: 1020 Recruitment Status: RECRUITING Condition: Venous Thromboembolism
NCTID: NCT00112554
Title: Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy, such as cytarabine and VNP40101M, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. PURPOSE: This randomized phase III trial is studying cytarabine and VNP40101M to see how well they work compared to cytarabine alone in treating patients with relapsed acute myeloid leukemia. Sponsor: Vion Pharmaceuticals Intervention: cytarabine Start Date: 2005-03 Last Updated: 2013-11-06 Number of Patients: 420 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT00089856
Title: GVAX® Vaccine for Prostate Cancer vs Docetaxel & Prednisone in Patients With Metastatic Hormone-Refractory Prostate Cancer Study Summary: The purpose of this study is to compare the duration of survival between GVAX® immunotherapy for prostate cancer and chemotherapy treatment in patients with prostate cancer who no longer respond to hormone therapy, who have documented metastases, and who have not been treated with chemotherapy in the past. Sponsor: Cell Genesys Intervention: Immunotherapy with allogeneic prostate vaccine Start Date: 2004-07 Last Updated: 2008-11-05 Number of Patients: 626 Recruitment Status: TERMINATED Condition: Prostate Cancer
NCTID: NCT00052156
Title: Vaccine Therapy for Patients With Stage IV Melanoma Study Summary: This is a Phase III study in patients with melanoma that has spread to the lymph nodes and/or a distant organ, and who have had all of their cancer surgically removed. The purpose of this study is to evaluate the ability of the CancerVax™ vaccine to prevent or slow the recurrence of melanoma. Sponsor: CancerVax Corporation Intervention: CancerVax vaccine (CANVAXIN) Start Date: NA Last Updated: 2005-06-24 Number of Patients: 670 Recruitment Status: UNKNOWN Condition: Malignant Melanoma
NCTID: NCT04996875
Title: (Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis Study Summary: This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM (ASM), SM with Associated Hematologic Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL). Sponsor: Cogent Biosciences, Inc. Intervention: bezuclastinib Start Date: 2021-11-09 Last Updated: 2023-10-25 Number of Patients: 120 Recruitment Status: RECRUITING Condition: Advanced Systemic Mastocytosis (AdvSM)
NCTID: NCT00003783
Title: Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug and combining drugs in different ways may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of chemotherapy in treating children who have very high risk acute lymphocytic leukemia. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 1999-03 Last Updated: 2014-07-28 Number of Patients: 36 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT01533207
Title: Gemcitabine Hydrochloride and Docetaxel Followed by Doxorubicin Hydrochloride or Observation in Treating Patients With High-Risk Uterine Leiomyosarcoma Previously Removed by Surgery Study Summary: This randomized phase III trial studies how well gemcitabine hydrochloride and docetaxel followed by doxorubicin hydrochloride work compared to observation in treating patients with high-risk uterine leiomyosarcoma previously removed by surgery. Drugs used in chemotherapy, such as gemcitabine hydrochloride, docetaxel, and doxorubicin hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether combination therapy after surgery is an effective treatment for uterine leiomyosarcoma. Sponsor: Gynecologic Oncology Group Intervention: Clinical Observation Start Date: 2012-06-04 Last Updated: 2020-04-28 Number of Patients: 38 Recruitment Status: TERMINATED Condition: Stage I Uterine Sarcoma AJCC v7
NCTID: NCT00003119
Title: Surgery in Treating Children With Neuroblastoma Study Summary: RATIONALE: Surgery alone may be effective in treating children with neuroblastoma. PURPOSE: Phase III trial to study the effectiveness of surgery alone in treating children who have neuroblastoma. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 1998-03 Last Updated: 2017-03-13 Number of Patients: 968 Recruitment Status: COMPLETED Condition: Neuroblastoma
NCTID: NCT05382286
Title: Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer Study Summary: The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician’s choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1). Sponsor: Gilead Sciences Intervention: Sacituzumab Govitecan-hziy Start Date: 2022-07-25 Last Updated: 2023-11-15 Number of Patients: 440 Recruitment Status: RECRUITING Condition: Triple Negative Breast Cancer
NCTID: NCT04211337
Title: A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid Cancer Study Summary: The reason for this study is to see if the study drug selpercatinib is safe and more effective compared to a standard treatment in participants with rearranged during transfection (RET)-mutant medullary thyroid cancer (MTC) that cannot be removed by surgery or has spread to other parts of the body. Participants who are assigned to the standard treatment and discontinue due to progressive disease have the option to potentially crossover to selpercatinib. Sponsor: Loxo Oncology, Inc. Intervention: Selpercatinib Start Date: 2020-02-11 Last Updated: 2023-10-30 Number of Patients: 291 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Medullary Thyroid Cancer
NCTID: NCT04980222
Title: A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma Study Summary: This Phase II, open-label, multicenter study will evaluate the safety, efficacy, and pharmacokinetics of glofitamab in combination with rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in individuals with circulating tumor DNA (ctDNA) high-risk diffuse large B-cell lymphoma (DLBCL), as the first line of treatment. Sponsor: Hoffmann-La Roche Intervention: Glofitamab Start Date: 2022-03-22 Last Updated: 2023-11-07 Number of Patients: 40 Recruitment Status: RECRUITING Condition: Lymphoma
NCTID: NCT05208047
Title: (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors Study Summary: This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll approximately 426 patients. Part 1 consists of two evaluations: 1) confirming the dose of an updated formulation of CGT9486 to be used in subsequent parts in approximately 20 patients who have received at least one prior line of therapy for GIST and 2) evaluating for drug-drug interactions between CGT9486 and sunitinib in approximately 18 patients who have received at least two prior tyrosine kinase inhibitors (TKIs) for GISTs. The second part of the study will enroll approximately 388 patients who are intolerant to, or who failed prior treatment with imatinib only and will compare the efficacy of CGT9486 plus sunitinib to sunitinib alone with patients being randomized in a 1:1 manner. Sponsor: Cogent Biosciences, Inc. Intervention: CGT9486 plus sunitinib Start Date: 2022-04-14 Last Updated: 2023-11-28 Number of Patients: 426 Recruitment Status: RECRUITING Condition: Advanced Gastrointestinal Stromal Tumors
NCTID: NCT04663347
Title: Safety and Efficacy Trial of Epcoritamab Combinations in Subjects With B-cell Non-Hodgkin Lymphoma (B-NHL) Study Summary: A phase 1b/2, open-label, multinational, interventional trial to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics/biomarkers, immunogenicity, and preliminary efficacy of epcoritamab (EPKINLY™) in combination with other standard of care (SOC) agents in participants with B-cell Non-Hodgkin Lymphoma (B-NHL). Sponsor: Genmab Intervention: rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone Start Date: 2020-11-03 Last Updated: 2023-08-08 Number of Patients: 662 Recruitment Status: RECRUITING Condition: Diffuse Large B-Cell Lymphoma
NCTID: NCT03975647
Title: A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer Study Summary: This study is being done to see if tucatinib with ado-trastuzumab emtansine (T-DM1) works better than T-DM1 alone to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. The breast cancer in this study is either metastatic (spread into other parts of the body) or cannot be removed completely with surgery. Patients in this study will be randomly assigned to get either tucatinib or placebo (a pill with no medicine). This is a blinded study, so neither patients nor their doctors will know whether a patient gets tucatinib or placebo. All patients in the study will get T-DM1, a drug that is often used to treat this cancer. Each treatment cycle lasts 21 days. Patients will swallow tucatinib pills or placebo pills two times every day. Patients will get T-DM1 injections from the study site staff on the first day of every cycle. Sponsor: Seagen Inc. Intervention: tucatinib Start Date: 2019-10-02 Last Updated: 2023-11-21 Number of Patients: 565 Recruitment Status: RECRUITING Condition: HER2-positive Breast Cancer
NCTID: NCT03037385
Title: Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors Study Summary: This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in participants with medullary thyroid cancer (MTC), RET-altered NSCLC and other RET-altered solid tumors. Sponsor: Hoffmann-La Roche Intervention: pralsetinib (BLU-667) Start Date: 2017-03-17 Last Updated: 2023-11-27 Number of Patients: 589 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: RET-altered Non Small Cell Lung Cancer
NCTID: NCT05173987
Title: Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15) Study Summary: The purpose of this study is to assess the safety and efficacy of treatment with pembrolizumab (MK-3475) compared to a combination of carboplatin and paclitaxel in women with mismatch repair deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy. The primary study hypotheses are that pembrolizumab is superior to the combination of carboplatin and paclitaxel with respect to Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and Overall Survival (OS). Sponsor: Merck Sharp & Dohme LLC Intervention: pembrolizumab Start Date: 2022-02-03 Last Updated: 2023-11-09 Number of Patients: 280 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Endometrial Neoplasms
NCTID: NCT03860883
Title: Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma Study Summary: Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life. Sponsor: Melanoma and Skin Cancer Trials Limited Intervention: Wide Local Excision = 1cm Margin Start Date: 2019-12-17 Last Updated: 2023-10-19 Number of Patients: 2998 Recruitment Status: RECRUITING Condition: Cutaneous Melanoma, Stage II
NCTID: NCT01479283
Title: Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Study Summary: The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial is the first ever international multi-center randomized controlled trial in bone cancer surgery. In order to avoid amputation for bone cancer in the leg, complex limb-saving operations are performed. However, infections with devastating complications following surgery are common. Surgeons from across the world will randomize patients to receive either short- or long-duration antibiotic regimens after surgery with the goal of identifying the best regimen to reduce these infections. Sponsor: McMaster University Intervention: 24-Hour Prophylactic Cefazolin* Antibiotic Regimen Start Date: 2013-01 Last Updated: 2021-03-11 Number of Patients: 602 Recruitment Status: COMPLETED Condition: Infection
NCTID: NCT00003671
Title: Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating children who have newly diagnosed acute lymphocytic leukemia. Sponsor: Children’s Oncology Group Intervention: asparaginase Start Date: 1998-12 Last Updated: 2014-07-25 Number of Patients: 59 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT00003739
Title: Antibiotic Therapy With or Without G-CSF in Treating Children With Neutropenia and Fever Caused by Chemotherapy Study Summary: RATIONALE: Antibiotics may decrease the side effects of neutropenia and fever caused by chemotherapy. Colony-stimulating factors such as G-CSF may increase the number of immune cells found in bone marrow or peripheral blood and may help a person’s immune system recover from the side effects of chemotherapy. It is not yet known whether antibiotic therapy plus G-CSF is more effective than antibiotic therapy alone for treating side effects caused by chemotherapy. PURPOSE: Randomized phase III trial to compare the effectiveness of antibiotic therapy with or without G-CSF in treating children who have neutropenia and fever that are caused by chemotherapy. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 1999-03 Last Updated: 2014-02-14 Number of Patients: 67 Recruitment Status: COMPLETED Condition: Fever, Sweats, and Hot Flashes
NCTID: NCT00019422
Title: Lobradimil and Carboplatin in Treating Children With Brain Tumors Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Lobradimil may increase the effectiveness of a chemotherapy drug by making tumor cells more sensitive to the drug. PURPOSE: Phase II trial to study the effectiveness of carboplatin and lobradimil in treating children with brain tumors that have not responded to previous treatment. Sponsor: National Cancer Institute (NCI) Intervention: carboplatin Start Date: 1998-03 Last Updated: 2013-08-16 Number of Patients: NA Recruitment Status: COMPLETED Condition: Brain and Central Nervous System Tumors
NCTID: NCT01796171
Title: A Phase I/II Study of Betalutin for Treatment of Relapsed Non-Hodgkin Lymphoma Study Summary: This study is a phase I/II open-label study in patients with relapsed indolent NHL (Part A) or relapsed/refractory FL (Part B). Part A of the study assessed the safety and preliminary efficacy. This seamless design study now has four parts: 1) Part A, Ph I - dose escalation, 2) Part A, Ph II - dose expansion, 3) Part B, Ph II randomized - refinement of dose, and 4) Part B and C, Phase II, single-arm. As of August 7, 2020, patients are enrolling in the fourth part of the study. Sponsor: Nordic Nanovector Intervention: Betalutin Start Date: 2012-12 Last Updated: 2022-09-14 Number of Patients: 191 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Non-Hodgkin Lymphoma
NCTID: NCT00088803
Title: DNA Variations in the Gene in Young Patients With Wilms’ Tumor Study Summary: RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. PURPOSE: This laboratory study is looking at DNA variations in the RASSF1A gene in young patients with Wilms’ tumor. Sponsor: Children’s Oncology Group Intervention: molecular genetic technique Start Date: 2004-08 Last Updated: 2016-05-19 Number of Patients: 471 Recruitment Status: COMPLETED Condition: Kidney Cancer
NCTID: NCT03940703
Title: A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2) Study Summary: This study will assess the antitumor activity, safety, tolerability, and pharmacokinetics (PK) of the Mesenchymal-epithelial Transition Factor (MET) inhibitor tepotinib combined with the 3rd generation EGFR inhibitor osimertinib in participants with advanced or metastatic non-small cell lung cancer (NSCLC). Sponsor: EMD Serono Research & Development Institute, Inc. Intervention: Tepotinib Start Date: 2019-09-19 Last Updated: 2023-08-29 Number of Patients: 120 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Non-small Cell Lung Cancer
NCTID: NCT03361865
Title: Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307) Study Summary: The purpose of this study was to evaluate the efficacy and safety of pembrolizumab + epacadostat vs pembrolizumab + placebo in participants with cisplatin-ineligible urothelial carcinoma. Sponsor: Incyte Corporation Intervention: Pembrolizumab Start Date: 2017-12-04 Last Updated: 2021-12-16 Number of Patients: 93 Recruitment Status: COMPLETED Condition: UC (Urothelial Cancer)
NCTID: NCT05118789
Title: A Study of NVL-520 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1) Study Summary: Phase 1/2, dose escalation and expansion study designed to evaluate the safety and tolerability of NVL-520, determine the recommended phase 2 dose (RP2D), and evaluate the antitumor activity in patients with advanced ROS1-positive (ROS1+) NSCLC and other advanced ROS1-positive solid tumors. Phase 1 will determine the RP2D and, if applicable, the maximum tolerated dose (MTD) of NVL-520 in patients with advanced ROS1-positive solid tumors. Phase 2 will determine the objective response rate (ORR) as assessed by Blinded Independent Central Review (BICR) of NVL-520 at the RP2D. Secondary objectives will include the duration of response (DOR), time to response (TTR), progression-free survival (PFS), overall survival (OS), and clinical benefit rate (CBR) of NVL-520 in patients with advanced ROS1-positive NSCLC and other solid tumors. Sponsor: Nuvalent Inc. Intervention: NVL-520 Start Date: 2022-01-04 Last Updated: 2023-11-07 Number of Patients: 359 Recruitment Status: RECRUITING Condition: Locally Advanced Solid Tumor
NCTID: NCT00006462
Title: Gemcitabine in Treating Children With Relapsed or Refractory Acute Lymphoblastic Leukemia or Acute Myelogenous Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of gemcitabine in treating children who have relapsed or refractory acute lymphoblastic leukemia or acute myelogenous leukemia. Sponsor: Children’s Oncology Group Intervention: gemcitabine hydrochloride Start Date: 2001-04 Last Updated: 2014-02-20 Number of Patients: 32 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT02617589
Title: An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) Study Summary: The purpose of this study is to evaluate patients with glioblastoma that is MGMT-unmethylated (the MGMT gene is not altered by a chemical change). Patients will receive Nivolumab every two weeks in addition to radiation therapy, and then every four weeks. They will be compared to patients receiving standard therapy with temozolomide in addition to radiation therapy. Sponsor: Bristol-Myers Squibb Intervention: Nivolumab Start Date: 2016-03-01 Last Updated: 2023-03-28 Number of Patients: 560 Recruitment Status: COMPLETED Condition: Brain Cancer
NCTID: NCT03149549
Title: PROCLAIM-CX-2009: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2009 for Patients With Selected Solid Tumors Study Summary: The purpose of this first-in-human study of CX-2009 is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of CX-2009 in adult subjects with metastatic or locally advanced unresectable solid tumors. PROCLAIM: PRObody CLinical Assessment In Man CX-2009 clinical trial 001 PROBODY is a trademark of CytomX Therapeutics, Inc Sponsor: CytomX Therapeutics Intervention: CX-2009 Start Date: 2017-06-01 Last Updated: 2021-08-04 Number of Patients: 99 Recruitment Status: COMPLETED Condition: Solid Tumor, Adult
NCTID: NCT00932893
Title: An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene Study Summary: This is a Phase 3 trial comparing the safety and anti-tumor activity of PF-02341066 versus pemetrexed or docetaxel in patients with advanced non-small cell lung cancer with specific gene profile involving the ALK gene after failure of one previous chemotherapy regimen that included one platinum drug. Sponsor: Pfizer Intervention: PF-02341066 Start Date: 2009-09 Last Updated: 2017-01-02 Number of Patients: 347 Recruitment Status: COMPLETED Condition: Carcinoma, Non-Small-Cell Lung
NCTID: NCT00003093
Title: Combination Chemotherapy in Treating Children With Neuroblastoma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Combination chemotherapy plus surgery may be an effective treatment for neuroblastoma. PURPOSE: This phase III trial is studying how well combination chemotherapy followed by surgery works in treating young patients with neuroblastoma. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 1988-03 Last Updated: 2014-08-01 Number of Patients: 573 Recruitment Status: COMPLETED Condition: Neuroblastoma
NCTID: NCT02725268
Title: A Study of Sapanisertib, Combination of Sapanisertib With MLN1117, Paclitaxel and Combination of Sapanisertib With Paclitaxel in Women With Endometrial Cancer Study Summary: The primary purpose of this study is to determine if sapanisertib in combination with weekly paclitaxel improves progression-free survival (PFS) compared to weekly paclitaxel alone. Sponsor: Millennium Pharmaceuticals, Inc. Intervention: Paclitaxel Start Date: 2016-04-01 Last Updated: 2021-11-24 Number of Patients: 241 Recruitment Status: COMPLETED Condition: Endometrial Neoplasms
NCTID: NCT00003593
Title: Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase III trial to study the effectiveness of combination chemotherapy in treating children who have Down syndrome and myeloproliferative disorder, acute myelogenous leukemia, or myelodysplastic syndrome. Sponsor: Children’s Oncology Group Intervention: asparaginase Start Date: 1999-06 Last Updated: 2013-06-27 Number of Patients: 254 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT00003745
Title: Chemotherapy in Treating Children With Recurrent or Refractory Sarcomas Study Summary: Phase II trial to study the effectiveness of topotecan in treating children who have recurrent, relapsed, or refractory sarcoma. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Sponsor: National Cancer Institute (NCI) Intervention: topotecan hydrochloride Start Date: 1999-05 Last Updated: 2013-02-05 Number of Patients: 125 Recruitment Status: COMPLETED Condition: Sarcoma
NCTID: NCT02375204
Title: Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Study Summary: This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors. Sponsor: Alliance for Clinical Trials in Oncology Intervention: paclitaxel Start Date: 2015-08-05 Last Updated: 2023-08-31 Number of Patients: 420 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Germ Cell Tumor
NCTID: NCT02718417
Title: Avelumab in Previously Untreated Patients With Epithelial Ovarian Cancer (JAVELIN OVARIAN 100) Study Summary: This is a Phase 3, open-label, international, multi-center, efficacy, and safety study of avelumab in combination with and/or following platinum-based chemotherapy. Eligible patients must have previously untreated, histologically confirmed Stage III-IV epithelial ovarian (EOC), fallopian tube cancer (FTC), or primary peritoneal cancer (PPC) and be candidates for platinum-based chemotherapy. The primary purpose of the study is to demonstrate if avelumab given as single agent in the maintenance setting following frontline chemotherapy or in combination with carboplatin/paclitaxel is superior to platinum-based chemotherapy alone followed by observation in this population of newly diagnosed ovarian cancer patients. Sponsor: Pfizer Intervention: carboplatin Start Date: 2016-05-19 Last Updated: 2020-07-14 Number of Patients: 998 Recruitment Status: TERMINATED Condition: Ovarian Cancer
NCTID: NCT02039726
Title: (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive Study Summary: The primary objective of the study is to determine whether quizartinib monotherapy prolongs overall survival (OS) compared to salvage chemotherapy in subjects with FMS-like tyrosine kinase 3 - Internal Tandem Duplication (FLT3-ITD) positive AML who are refractory to or have relapsed within 6 months, after first-line AML therapy. Sponsor: Daiichi Sankyo, Inc. Intervention: Quizartinib Start Date: 2014-05 Last Updated: 2021-02-24 Number of Patients: 367 Recruitment Status: COMPLETED Condition: AML
NCTID: NCT01212991
Title: A Safety and Efficacy Study of Oral MDV3100 in Chemotherapy-Naive Patients With Progressive Metastatic Prostate Cancer Study Summary: The purpose of this study is to determine the benefit of enzalutamide versus placebo as assessed by overall survival and progression-free survival in patients with progressive metastatic prostate cancer who have failed androgen deprivation therapy but not yet received chemotherapy. Sponsor: Pfizer Intervention: Enzalutamide Start Date: 2010-09-16 Last Updated: 2020-03-17 Number of Patients: 1717 Recruitment Status: COMPLETED Condition: Prostate Cancer
NCTID: NCT05041309
Title: Long-term Follow-up Study for Participants of Kite-Sponsored Interventional Studies Treated With Gene-Modified Cells Study Summary: The goal of this clinical study is to learn more about the long-term safety, effectiveness and prolonged action of Kite study drugs, axicabtagene ciloleucel, brexucabtagene autoleucel, KITE-222, KITE-363, KITE-439, KITE-585, and KITE-718, in participants of Kite-sponsored interventional studies. Sponsor: Kite, A Gilead Company Intervention: Axicabtagene Ciloleucel Start Date: 2021-12-15 Last Updated: 2023-11-07 Number of Patients: 700 Recruitment Status: ENROLLING_BY_INVITATION Condition: Solid and Hematological Malignancies
NCTID: NCT02273375
Title: Double Blind Placebo Controlled Controlled Study of Adjuvant MEDI4736 In Completely Resected NSCLC Study Summary: The purpose of this study is to find out whether it is better to receive a new drug, MEDI4736, or better to receive no further treatment after surgery (and possibly chemotherapy) for lung cancer. Sponsor: Canadian Cancer Trials Group Intervention: MEDI4736 Start Date: 2015-02-24 Last Updated: 2023-10-27 Number of Patients: 1415 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Non-Small Cell Lung Cancer
NCTID: NCT04950075
Title: Study of INBRX-109 in Conventional Chondrosarcoma Study Summary: Randomized, blinded, placebo-controlled, Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients. Sponsor: Inhibrx, Inc. Intervention: INBRX-109 Start Date: 2021-09-23 Last Updated: 2023-11-08 Number of Patients: 201 Recruitment Status: RECRUITING Condition: Conventional Chondrosarcoma
NCTID: NCT00052130
Title: Vaccine Therapy for Patients With Stage III Melanoma Study Summary: This is a Phase 3 study in patients with melanoma that has spread to the lymph nodes (stage III), and who have had all of their cancer surgically removed. The purpose of this study is to evaluate the ability of the CancerVax™ vaccine to prevent or slow the recurrence of melanoma. Sponsor: CancerVax Corporation Intervention: CancerVax vaccine (CANVAXIN) Start Date: NA Last Updated: 2005-06-24 Number of Patients: 1118 Recruitment Status: UNKNOWN Condition: Malignant Melanoma
NCTID: NCT03580655
Title: (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis Study Summary: This is an open-label, single arm, Phase 2 study evaluating the efficacy and safety of avapritinib (BLU-285) in patients with advanced systemic mastocytosis (AdvSM), including patients with aggressive SM (ASM), SM with associated hematologic neoplasm (SM-AHN), and mast cell leukemia (MCL) Sponsor: Blueprint Medicines Corporation Intervention: Avapritinib Start Date: 2018-11-21 Last Updated: 2023-08-02 Number of Patients: 103 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Advanced Systemic Mastocytosis
NCTID: NCT00002851
Title: Lymph Node Radiation Therapy in Patients With Stage I, Stage II, or Stage III Breast Cancer That Has Been Surgically Removed Study Summary: RATIONALE: Radiation therapy may kill any tumor cells remaining after surgery. PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared to no further therapy in treating women with stage I, stage II, or stage III breast cancer that has been surgically removed. Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Intervention: adjuvant therapy Start Date: 1996-07 Last Updated: 2010-01-29 Number of Patients: 4000 Recruitment Status: UNKNOWN Condition: Breast Cancer
NCTID: NCT01986348
Title: Study Evaluating the Efficacy and Safety of Selinexor (KPT-330) in Participants With Recurrent Gliomas Study Summary: This is an open-label, multicenter, Phase 2 study to evaluate the efficacy and safety of oral selinexor in participants with recurrent gliomas. Sponsor: Karyopharm Therapeutics Inc Intervention: Selinexor Start Date: 2014-03-03 Last Updated: 2023-01-26 Number of Patients: 76 Recruitment Status: TERMINATED Condition: Glioblastoma
NCTID: NCT04250155
Title: An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors Study Summary: This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 alone or in combination with a checkpoint inhibitor treatment in participants with locally advanced or metastatic solid tumors. Sponsor: Genentech, Inc. Intervention: XmAb24306 Start Date: 2020-03-09 Last Updated: 2023-11-24 Number of Patients: 250 Recruitment Status: RECRUITING Condition: Solid Tumors
NCTID: NCT00547651
Title: AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy Study Summary: This study drug (Amrubicin) is believed to work by stopping the tumor cells in your body from growing. The purpose of this study is to evaluate the effect of amrubicin compared to topotecan in the treatment of small cell lung cancer. Sponsor: Celgene Intervention: Amrubicin Start Date: 2007-09-01 Last Updated: 2019-11-06 Number of Patients: 637 Recruitment Status: COMPLETED Condition: Small Cell Lung Cancer
NCTID: NCT03915951
Title: An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer Study Summary: This is an open-label, multicenter, non-randomized, Phase 2 study to determine the safety, tolerability and efficacy of encorafenib given in combination with binimetinib in patients with BRAFV600E-mutant metastatic non-small cell lung cancer (NSCLC). Patients who are either treatment-naïve, OR who have received 1) first-line treatment with standard platinum-based chemotherapy, OR 2) first-line treatment with an anti-programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitor given alone or in combination with platinum-based chemotherapy will be enrolled. Sponsor: Pfizer Intervention: encorafenib Start Date: 2019-06-04 Last Updated: 2023-10-30 Number of Patients: 98 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Non-small Cell Lung Cancer
NCTID: NCT02319837
Title: Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK) Study Summary: The purpose of this study is to assess enzalutamide plus leuprolide in patients with high-risk nonmetastatic prostate cancer progressing after radical prostatectomy or radiotherapy or both. The randomized / blinded portion of the study is now completed following primary endpoint analyses. The study remains ongoing in open label format. Sponsor: Pfizer Intervention: Enzalutamide Start Date: 2014-12-17 Last Updated: 2023-08-08 Number of Patients: 1068 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Hormone Sensitive Prostate Cancer
NCTID: NCT00003937
Title: Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Chemoprotective drugs such as dexrazoxane may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase III trial to study the effectiveness of three combination chemotherapy regimens plus dexrazoxane in treating patients who have newly diagnosed nonmetastatic osteosarcoma. Sponsor: Children’s Oncology Group Intervention: cisplatin Start Date: 1999-09 Last Updated: 2014-08-05 Number of Patients: 253 Recruitment Status: COMPLETED Condition: Cardiac Toxicity
NCTID: NCT01059630
Title: A Study to Investigate the Efficacy and Safety of Bendamustine Compared With Bendamustine+Obinutuzumab (GA101) in Participants With Rituximab-Refractory, Indolent Non-Hodgkin’s Lymphoma (GADOLIN) Study Summary: This open-label, multicenter, randomized Phase III study will investigate the efficacy, safety, pharmacokinetics and pharmacoeconomics of obinutuzumab (RO5072759, GA101) combined with bendamustine followed by continued obinutuzumab treatment (maintenance monotherapy) compared with bendamustine alone treatment in participants with rituximab-refractory indolent Non-Hodgkin’s lymphoma (iNHL). The end of study was defined to when safety follow-up for all patients had been completed (2 years’ safety follow-up from last dose). Sponsor: Genentech, Inc. Intervention: Obinutuzumab Start Date: 2010-04-30 Last Updated: 2020-01-13 Number of Patients: 413 Recruitment Status: COMPLETED Condition: Non-Hodgkin’s Lymphoma
NCTID: NCT05079230
Title: Study of Magrolimab Versus Placebo in Combination With Venetoclax and Azacitidine in Participants With Acute Myeloid Leukemia Study Summary: The goal of this clinical study is to compare the study drugs, magrolimab + venetoclax + azacitidine, versus placebo + venetoclax + azacitidine in participants with untreated acute myeloid leukemia (AML) who are not able to have chemotherapy. Sponsor: Gilead Sciences Intervention: Magrolimab Start Date: 2022-07-07 Last Updated: 2023-10-30 Number of Patients: 432 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Acute Myeloid Leukemia
NCTID: NCT00932451
Title: An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene Study Summary: This is a Phase 2 trial that will evaluate the safety and efficacy of PF-02341066 in patients with advanced non-small cell lung cancer with a specific gene profile involving the ALK gene. This trial will also allow patients from a Phase 3 trial who received standard of care chemotherapy (Study A8081007) to receive PF-02341066. Sponsor: Pfizer Intervention: PF-02341066 Start Date: 2010-01 Last Updated: 2017-01-13 Number of Patients: 1069 Recruitment Status: COMPLETED Condition: Carcinoma, Non-Small-Cell Lung
NCTID: NCT05076942
Title: Groningen International Study on Sentinel Nodes in Vulvar Cancer-III Study Summary: Vulvar cancer patients with SN-metastasis > 2mm will receive chemoradiation instead of an inguinofemoral lymphadenectomy. Sponsor: University Medical Center Groningen Intervention: Radiotherapy combined with cisplatin Start Date: 2021-01-01 Last Updated: 2023-08-01 Number of Patients: 157 Recruitment Status: RECRUITING Condition: Vulvar Cancer
NCTID: NCT05153330
Title: Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL Study Summary: A Phase 1 first-in-human dose-escalation and dose-expansion study of BMF-219, an oral covalent menin inhibitor, in adult patients with AML, ALL (with KMT2A/ MLL1r, NPM1 mutations), DLBCL, MM, and CLL/SLL. Sponsor: Biomea Fusion Inc. Intervention: BMF-219 Start Date: 2022-01-24 Last Updated: 2023-10-06 Number of Patients: 177 Recruitment Status: RECRUITING Condition: Acute Myeloid Leukemia
NCTID: NCT02450331
Title: A Study of Atezolizumab Versus Observation as Adjuvant Therapy in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (UC) After Surgical Resection Study Summary: This Phase III, open-label, randomized, multicenter study is to evaluate the efficacy and safety of adjuvant treatment with atezolizumab compared with observation in participants with muscle-invasive UC who are at high risk for recurrence following resection. Eligible participants were randomized by a 1:1 ratio into atezolizumab group or control group. Sponsor: Hoffmann-La Roche Intervention: Atezolizumab Start Date: 2015-10-05 Last Updated: 2023-06-18 Number of Patients: 809 Recruitment Status: TERMINATED Condition: Carcinoma, Transitional Cell
NCTID: NCT00005585
Title: Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different regimens of combination chemotherapy to see how well they work in treating children with acute lymphoblastic leukemia. Sponsor: Children’s Oncology Group Intervention: cyclophosphamide Start Date: 2000-04 Last Updated: 2023-04-06 Number of Patients: 838 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT03391466
Title: Study of Effectiveness of Axicabtagene Ciloleucel Compared to Standard of Care Therapy in Patients With Relapsed/Refractory Diffuse Large B Cell Lymphoma Study Summary: The goal of this clinical study is to assess whether axicabtagene ciloleucel therapy improves the clinical outcome compared with standard of care second-line therapy in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Sponsor: Kite, A Gilead Company Intervention: Axicabtagene Ciloleucel Start Date: 2018-01-25 Last Updated: 2023-07-06 Number of Patients: 359 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
NCTID: NCT00003625
Title: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Brain Stem Glioma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating patients with newly diagnosed brain stem glioma. Sponsor: Children’s Oncology Group Intervention: cyclosporine Start Date: 1998-12 Last Updated: 2014-07-28 Number of Patients: 7 Recruitment Status: COMPLETED Condition: Brain Tumors
NCTID: NCT00027846
Title: Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for Ependymoma Study Summary: RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy before surgery may shrink the tumor so that it can be removed during surgery. PURPOSE: Phase II trial to determine the effectiveness of specialized radiation therapy either alone or after chemotherapy and second surgery in treating children who have undergone surgery for localized ependymoma. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 2003-08 Last Updated: 2019-08-07 Number of Patients: 378 Recruitment Status: COMPLETED Condition: Brain Tumor
NCTID: NCT01909453
Title: Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma Study Summary: This is 2-part, randomized, open label, multi-center, parallel group, phase III study comparing the efficacy and safety of LGX818 plus MEK162 to vemurafenib and LGX818 monotherapy in patients with locally advanced unresectable or metastatic melanoma with BRAF V600 mutation. A total of approximately 900 patients will be randomized. Part 1: Patients will be randomized in a 1:1:1 ratio to one of 3 treatment arms: # LGX818 450 mg QD plus MEK162 45 mg BID (denoted as Combo 450 arm) # LGX818 300 mg QD monotherapy (denoted as LGX818 arm) or # vemurafenib 960 mg BID (denoted as vemurafenib arm) Part 2: Patients will be randomized in a 3:1 ratio to one of the 2 treatment arms: # LGX818 300 mg QD plus MEK162 45 mg BID (denoted as Combo 300 arm) or # LGX818 300 mg QD monotherapy (denoted as LGX818 arm) Sponsor: Pfizer Intervention: LGX818 Start Date: 2013-12-13 Last Updated: 2023-09-07 Number of Patients: 921 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Melanoma
NCTID: NCT01189253
Title: Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Study Summary: RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride and trabectedin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether trabectedin is more effective than doxorubicin hydrochloride in treating patients with advanced or metastatic soft tissue sarcoma. PURPOSE: This randomized phase II/III trial is studying the safety of trabectedin compared with doxorubicin hydrochloride and to see how well they work in treating patients with advanced or metastatic soft tissue sarcoma. Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Intervention: doxorubicin hydrochloride Start Date: 2011-05 Last Updated: 2014-08-08 Number of Patients: 133 Recruitment Status: TERMINATED Condition: Sarcoma
NCTID: NCT00003573
Title: Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced Medulloblastoma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of etoposide plus radiation therapy followed by combination chemotherapy in treating children with newly diagnosed advanced medulloblastoma. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 1998-11 Last Updated: 2014-07-25 Number of Patients: 53 Recruitment Status: COMPLETED Condition: Brain Tumors
NCTID: NCT00005977
Title: Combination Chemotherapy in Treating Patients With Non-Hodgkin’s Lymphoma or Acute Lymphocytic Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have non-Hodgkin’s lymphoma or acute lymphocytic leukemia. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 2000-09 Last Updated: 2013-08-21 Number of Patients: 83 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT03731260
Title: (PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis Study Summary: This is a Phase 2, randomized, double-blind, placebo-controlled study comparing the efficacy and safety of avapritinib + best supportive care (BSC) with placebo + BSC in patients with indolent systemic mastocytosis (ISM) whose symptoms are not adequately controlled by BSC. The study will be conducted in 3 parts. All patients will receive treatment with avapritinib during Part 3 including those rolling over from the placebo group. Sponsor: Blueprint Medicines Corporation Intervention: Avapritinib Start Date: 2019-04-16 Last Updated: 2023-06-15 Number of Patients: 251 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Indolent Systemic Mastocytosis
NCTID: NCT03486873
Title: Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) Study Summary: The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this extension study. This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. Each participant will transition to this extension study in one of the following three phases, depending on the study phase they were in at the completion of the parent study. Participants who were in the First Course Phase of study treatment in their parent study will enter the First Course Phase of this study and complete up to 35 doses or more every 3 weeks (Q3W) or 17 doses or more every 6 weeks (Q6W) of study treatment with pembrolizumab or a pembrolizumab-based combination according to arm assignment. Participants who were in the Follow-up Phase in the parent study (post-treatment or Survival Follow-up Phase) will enter the Survival Follow-up Phase of this study. Participants who were in the Second Course Phase in their parent study will enter Second Course Phase of this study and complete up to 17 doses Q3W or 8 doses Q6W of study treatment with pembrolizumab or a pembrolizumab-based combination according to arm assignment. Any participant originating from a parent trial where crossover to pembrolizumab was permitted upon disease progression may be may be eligible for 35 doses as Q3W or 17 doses Q6W of pembrolizumab (approximately 2 years), if they progress while on the control arm and pembrolizumab is approved for the indication in the country where the potential eligible crossover participant is being evaluated. Sponsor: Merck Sharp & Dohme LLC Intervention: Pembrolizumab Start Date: 2018-08-21 Last Updated: 2023-11-27 Number of Patients: 2300 Recruitment Status: RECRUITING Condition: Solid Tumors
NCTID: NCT02598661
Title: Study to Evaluate Imetelstat (GRN163L) in Subjects With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) Study Summary: The purpose of this study is to evaluate the efficacy and safety of imetelstat in transfusion-dependent participants with low or intermediate-1 risk myelodysplastic syndrome (MDS) that is relapsed/refractory to erythropoiesis-stimulating agent (ESA) treatment in Part 1 of the study and to compare the efficacy, in terms of red blood cell (RBC) transfusion independence (TI), of imetelstat to placebo in transfusion-dependent participants with low or intermediate-1 risk MDS that is relapsed/refractory to ESA treatment in Part 2 of the study. An Extension Phase has been included to allow continued treatment for those subjects who are benefitting from imetelstat and to continue to evaluate the long-term safety, overall survival (OS), and disease progression, including progression to acute myeloid leukemia (AML) in transfusion-dependent participants with low or immediate-1 risk MDS that is relapsed/refractory to ESA treatment. Sponsor: Geron Corporation Intervention: Imetelstat Start Date: 2015-11-24 Last Updated: 2023-11-18 Number of Patients: 289 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Myelodysplastic Syndromes
NCTID: NCT00028795
Title: Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Giving chemotherapy together with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving chemotherapy together with radiation therapy after surgery followed by chemotherapy alone works in children with newly diagnosed astrocytoma, glioblastoma multiforme, gliosarcoma, or diffuse intrinsic pontine glioma. Sponsor: Children’s Oncology Group Intervention: temozolomide Start Date: 2002-12 Last Updated: 2014-02-21 Number of Patients: 170 Recruitment Status: COMPLETED Condition: Brain and Central Nervous System Tumors
NCTID: NCT03374488
Title: Pembrolizumab + Epacadostat vs Pembrolizumab + Placebo in Recurrent or Progressive Metastatic Urothelial Carcinoma Study Summary: The purpose of this study was to evaluate the efficacy and safety of pembrolizumab + epacadostat vs pembrolizumab + placebo as a treatment for recurrent or progressive metastatic urothelial carcinoma in patients who have failed a first-line platinum-containing chemotherapy regimen for advanced/metastatic disease. Sponsor: Incyte Corporation Intervention: Pembrolizumab Start Date: 2017-12-22 Last Updated: 2021-11-30 Number of Patients: 84 Recruitment Status: COMPLETED Condition: UC (Urothelial Cancer)
NCTID: NCT03345095
Title: A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma Study Summary: The standard of care for newly diagnosed glioblastoma includes surgery, involved-field radiotherapy, and concomitant and six cycles of maintenance temozolomide chemotherapy, however the prognosis remains dismal. Marizomib has been tested in patients with newly diagnosed and recurrent glioblastoma in phase I and phase II studies. In patients with recurrent glioblastoma, marizomib was administered as a single agent or in combination with bevacizumab (NCT02330562). Based on encouraging observations, a phase I/II trial of marizomib in combination with TMZ/RT –>TMZ in newly diagnosed glioblastoma has been launched (NCT02903069) which explores safety and tolerability of this triple combination and which shall help to determine the dose for further clinical trials in glioblastoma. In this context, given that marizomib has been established as a safe addition to the standard TMZ/RT –>TMZ, a phase III study is considered essential to establishing its impact on overall survival. Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Intervention: Marizomib Start Date: 2018-07-26 Last Updated: 2023-05-24 Number of Patients: 749 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Newly Diagnosed Glioblastoma
NCTID: NCT00002995
Title: Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Study Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether chemotherapy is more effective with or without radiation therapy in treating patients who have rhabdomyosarcoma. PURPOSE: Phase III trial to compare the effectiveness of chemotherapy with or without radiation therapy in treating patients who have newly-diagnosed rhabdomyosarcoma. Sponsor: Children’s Oncology Group Intervention: dactinomycin Start Date: 1997-08 Last Updated: 2014-02-14 Number of Patients: 483 Recruitment Status: COMPLETED Condition: Sarcoma
NCTID: NCT00002594
Title: Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so that they stop growing or die. bone marrow transplantation and peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by bone marrow transplantation and/or peripheral stem cell transplantation in treating patients who have recurrent medulloblastoma or CNS germ cell tumors. Sponsor: Children’s Oncology Group Intervention: Sargramostim Start Date: 1994-09 Last Updated: 2014-07-24 Number of Patients: 31 Recruitment Status: COMPLETED Condition: Brain Tumor
NCTID: NCT00002610
Title: Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. It is not yet known which therapy regimen is most effective for treating patients with kidney tumors. PURPOSE: Phase III trial to compare the effectiveness of chemotherapy with or without radiation therapy, surgery, and/or peripheral stem cell or bone marrow transplantation in treating young patients with kidney tumors. Sponsor: Children’s Oncology Group Intervention: dactinomycin Start Date: 1996-01 Last Updated: 2014-07-25 Number of Patients: 203 Recruitment Status: COMPLETED Condition: Kidney Cancer
NCTID: NCT00003955
Title: Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy combined with radiation therapy in treating patients who have metastatic rhabdomyosarcoma or sarcoma. Sponsor: Children’s Oncology Group Intervention: dactinomycin Start Date: 1999-09 Last Updated: 2014-02-14 Number of Patients: 77 Recruitment Status: COMPLETED Condition: Sarcoma
NCTID: NCT03061812
Title: Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) Study Summary: The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of DLL3, who have first disease progression during or following front-line platinum-based chemotherapy. Sponsor: AbbVie Intervention: Rovalpituzumab tesirine Start Date: 2017-04-11 Last Updated: 2021-02-23 Number of Patients: 444 Recruitment Status: COMPLETED Condition: Small Cell Lung Cancer
NCTID: NCT00887146
Title: Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Study Summary: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma. Sponsor: Alliance for Clinical Trials in Oncology Intervention: concomitant temozolomide (TMZ) Start Date: 2009-09 Last Updated: 2023-11-01 Number of Patients: 360 Recruitment Status: RECRUITING Condition: Brain and Central Nervous System Tumors
NCTID: NCT04222972
Title: A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC) Study Summary: This is an international, randomized, open-label, Phase 3 study designed to evaluate whether the potent and selective RET inhibitor, pralsetinib, improves outcomes when compared to a platinum chemotherapy-based regimen chosen by the Investigator from a list of standard of care treatments, as measured primarily by progression free survival (PFS), for participants with RET fusion-positive metastatic NSCLC who have not previously received systemic anticancer therapy for metastatic disease. Participants who have centrally confirmed progressive disease on the control arm have the option to crossover to pralsetinib. Sponsor: Hoffmann-La Roche Intervention: Pralsetinib Start Date: 2020-07-24 Last Updated: 2023-11-13 Number of Patients: 226 Recruitment Status: RECRUITING Condition: RET-fusion Non Small Cell Lung Cancer
NCTID: NCT04358458
Title: First-in-Human (FIH) Trial of GEN3009 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas Study Summary: The drug that will be investigated in the study is an antibody, GEN3009. Since this is the first study of GEN3009 in humans, the main purpose is to evaluate safety. Besides safety, the study will determine the recommended GEN3009 dose to be tested in a larger group of patients and assess preliminary clinical activity of GEN3009. GEN3009 will be studied in a broad group of cancer patients, having different kinds of lymphomas. All patients will get GEN3009 either as a single treatment (monotherapy) or in combination with another antibody-candidate for treatment of cancer in the blood. The study consists of two parts: Part 1 tests increasing doses of GEN3009 (“escalation”), followed by Part 2 which tests the recommended GEN3009 dose from Part 1 (“expansion”). Sponsor: Genmab Intervention: GEN3009 Start Date: 2020-03-24 Last Updated: 2023-09-21 Number of Patients: 46 Recruitment Status: TERMINATED Condition: Diffuse Large B-cell Lymphoma
NCTID: NCT02580058
Title: A Study Of Avelumab Alone Or In Combination With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer (JAVELIN Ovarian 200) Study Summary: A Phase 3 global study comparing avelumab alone to avelumab plus PLD and to PLD alone to demonstrate that avelumab given alone or in combination with PLD is superior to PLD alone in prolonging Overall Survival in patients with platinum resistant/platinum refractory ovarian cancer. Sponsor: Pfizer Intervention: avelumab Start Date: 2015-12-21 Last Updated: 2023-07-10 Number of Patients: 566 Recruitment Status: COMPLETED Condition: Ovarian Cancer
NCTID: NCT00005596
Title: Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of chemotherapy is more effective for acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing four regimens of combination chemotherapy to see how well they work in treating children with newly diagnosed acute lymphoblastic leukemia. Sponsor: Children’s Oncology Group Intervention: cyclophosphamide Start Date: 2000-04 Last Updated: 2023-04-06 Number of Patients: 1076 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT05361395
Title: First-Line Tarlatamab in Combination With Carboplatin, Etoposide, and PD-L1 Inhibitor in Subjects With Extensive Stage Small Cell Lung Cancer (ES-SCLC) Study Summary: This is a phase 1b study to assess the safety and tolerability of tarlatamab in combination with programmed death ligand (PD-L1) inhibition with and without chemotherapy. Sponsor: Amgen Intervention: Tarlatamab Start Date: 2022-08-24 Last Updated: 2023-11-09 Number of Patients: 340 Recruitment Status: RECRUITING Condition: Extensive Stage Small Cell Lung Cancer
NCTID: NCT00056069
Title: Study of the Physical and Emotional Needs of Parents Caring for Children Receiving Chemotherapy for Acute Lymphoblastic Leukemia Study Summary: RATIONALE: Studying the physical and emotional needs of parents who are caring for children receiving chemotherapy for cancer may help doctors plan effective treatments for the patient that allow for improved quality of life of the patient’s family. PURPOSE: This clinical trial is studying the different physical and emotional needs of parents whose children are undergoing chemotherapy for acute lymphoblastic leukemia either in an outpatient clinic or in the hospital. Sponsor: Children’s Oncology Group Intervention: questionnaire administration Start Date: 2002-12 Last Updated: 2015-05-07 Number of Patients: 172 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT00003935
Title: Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem Glioma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of vincristine plus etoposide and radiation therapy in treating children who have newly diagnosed brain stem glioma. Sponsor: Children’s Oncology Group Intervention: etoposide Start Date: 1999-09 Last Updated: 2014-07-28 Number of Patients: 31 Recruitment Status: COMPLETED Condition: Brain Tumors
NCTID: NCT00865969
Title: Belinostat in Relapsed or Refractory Peripheral T-Cell Lymphoma Study Summary: The purpose of this study is to assess efficacy and safety of belinostat in participants with relapsed or refractory peripheral T-cell lymphoma (PTCL), who failed at least one prior systemic therapy. Sponsor: Spectrum Pharmaceuticals, Inc Intervention: Belinostat Start Date: 2008-12-15 Last Updated: 2021-10-29 Number of Patients: 129 Recruitment Status: COMPLETED Condition: Peripheral T-cell Lymphoma
NCTID: NCT01734928
Title: Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma Study Summary: The purpose of this study is to compare the efficacy of the combination of pomalidomide, bortezomib and low dose dexamethasone to the combination of bortezomib and low dose dexamethasone in participants with relapsed/refractory multiple myeloma. This study will also assess how safe the combination of pomalidomide, bortezomib and low dose dexamethasone is compared to the combination of bortezomib and low dose dexamethasone. Sponsor: Celgene Intervention: Pomalidomide Start Date: 2013-01-07 Last Updated: 2023-06-06 Number of Patients: 559 Recruitment Status: COMPLETED Condition: Multiple Myeloma
NCTID: NCT02088541
Title: Selinexor (KPT-330) in Older Patients With Relapsed AML Study Summary: This is a randomized, multicenter, open-label, phase 2 study of the SINE compound, selinexor given orally versus specified investigator choices (one of three potential salvage therapies). Participants age ≥ 60 years with relapsed or refractory AML of any type except for AML M3, after one prior therapy only, who have never undergone and who are not currently eligible for stem cell transplantation and are currently deemed unfit for intensive chemotherapy. Sponsor: Karyopharm Therapeutics Inc Intervention: Selinexor Start Date: 2014-03 Last Updated: 2023-01-26 Number of Patients: 317 Recruitment Status: COMPLETED Condition: Acute Myeloid Leukemia (AML)
NCTID: NCT01510184
Title: Study of Zevalin Versus Observation in Participants at Least 60 Years Old With Newly Diagnosed Diffuse Large B-cell Lymphoma in Positron Emission Tomography (PET)-Negative Complete Remission After Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) or R-CHOP-like Therapy Study Summary: The purpose of this study is to evaluate the efficacy and safety of Zevalin compared with observation alone in participants who are in PET-negative complete remission after first-line R-CHOP or R-CHOP like therapy. Sponsor: Spectrum Pharmaceuticals, Inc Intervention: Zevalin Start Date: 2012-04-19 Last Updated: 2021-12-16 Number of Patients: 79 Recruitment Status: TERMINATED Condition: Diffuse Large B-cell Lymphoma
NCTID: NCT00904241
Title: Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Study Summary: This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. Sponsor: Children’s Oncology Group Intervention: Cytology Specimen Collection Procedure Start Date: 2000-11-06 Last Updated: 2023-04-13 Number of Patients: 10000 Recruitment Status: RECRUITING Condition: Ganglioneuroblastoma
NCTID: NCT00006102
Title: Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin’s Lymphoma Study Summary: Phase II trial to study the effectiveness of rebeccamycin analogue in treating children who have solid tumors or non-Hodgkin’s lymphoma. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Sponsor: National Cancer Institute (NCI) Intervention: becatecarin Start Date: 2000-07 Last Updated: 2013-02-05 Number of Patients: 200 Recruitment Status: COMPLETED Condition: Brain and Central Nervous System Tumors
NCTID: NCT00004932
Title: STI571 in Treating Patients With Recurrent Leukemia Study Summary: RATIONALE: Imatinib mesylate may interfere with the growth of cancer cells and may be an effective treatment for leukemia. PURPOSE: Phase I trial to study the effectiveness of imatinib mesylate in treating patients who have recurrent leukemia. Sponsor: Children’s Oncology Group Intervention: imatinib mesylate Start Date: 2002-01 Last Updated: 2014-02-21 Number of Patients: 31 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT00021242
Title: Docetaxel in Treating Children With Relapsed or Refractory Acute Lymphoblastic or Acute Myeloid Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of docetaxel in treating children who have relapsed or refractory acute lymphoblastic or acute myeloid leukemia. Sponsor: Children’s Oncology Group Intervention: docetaxel Start Date: 2002-08 Last Updated: 2014-08-08 Number of Patients: 12 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT05239728
Title: A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022) Study Summary: The purpose of this study is to assess the efficacy and safety of oral belzutifan (MK-6482) plus intravenous (IV) pembrolizumab (MK-3475) compared to placebo plus pembrolizumab, in the adjuvant treatment of Clear Cell Renal Cell Carcinoma (ccRCC) post nephrectomy. The primary study hypothesis is that belzutifan plus pembrolizumab is superior to placebo plus pembrolizumab with respect to disease-free survival (DFS). Sponsor: Merck Sharp & Dohme LLC Intervention: Belzutifan Start Date: 2022-03-15 Last Updated: 2023-11-28 Number of Patients: 1800 Recruitment Status: RECRUITING Condition: Carcinoma, Renal Cell
NCTID: NCT00003178
Title: Chemotherapy in Treating Children With Recurrent Acute Myeloid Leukemia Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of idarubicin and cladribine in treating children who have recurrent acute myeloid leukemia. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 1998-03 Last Updated: 2014-07-25 Number of Patients: 120 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT02714218
Title: A Study of Two Different Dose Combinations of Nivolumab in Combination With Ipilimumab in Subjects With Previously Untreated, Unresectable or Metastatic Melanoma Study Summary: The purpose of this study is to evaluate two different dose combinations of nivolumab and ipilimumab in the treatment of melanoma. Sponsor: Bristol-Myers Squibb Intervention: Nivolumab 3 mg/kg IV Start Date: 2016-04-04 Last Updated: 2022-06-24 Number of Patients: 387 Recruitment Status: COMPLETED Condition: Melanoma
NCTID: NCT02031458
Title: A Study of Atezolizumab in Participants With Programmed Death - Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer Study Summary: This multicenter, single-arm study will evaluate the efficacy and safety of Atezolizumab in participants with PD-L1-positive locally advanced or metastatic non-small cell lung cancer (NSCLC). Participants will receive Atezolizumab 1200 milligrams (mg) intravenously every 3 weeks as long as participants are experiencing clinical benefit as assessed by the investigator, that is , in the absence of unacceptable toxicity or symptomatic deterioration attributed to disease progression. Sponsor: Hoffmann-La Roche Intervention: Atezolizumab Start Date: 2014-01-22 Last Updated: 2020-01-06 Number of Patients: 667 Recruitment Status: COMPLETED Condition: Non-Small Cell Lung Cancer
NCTID: NCT00005584
Title: Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin’s Lymphoma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining chemotherapy with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin’s lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of different regimens of combination chemotherapy with or without radiation therapy in treating patients who have Hodgkin’s lymphoma. Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Intervention: bleomycin sulfate Start Date: 1998-10 Last Updated: 2023-02-15 Number of Patients: 1649 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Lymphoma
NCTID: NCT03673501
Title: A Study of DCC-2618 vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib Study Summary: This is a 2-arm, randomized, open-label, international, multicenter study comparing the efficacy of DCC-2618 to sunitinib in GIST patients who progressed on or were intolerant to first-line anticancer treatment with imatinib. Approximately 426 patients will be randomized in a 1:1 ratio to DCC-2618 150 mg once daily (QD) (continuous dosing for 6 week cycles) or sunitinib 50 mg QD (6 week cycles, 4 weeks on, 2 weeks off). Sponsor: Deciphera Pharmaceuticals LLC Intervention: DCC-2618 Start Date: 2019-02-11 Last Updated: 2021-01-06 Number of Patients: 426 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Gastrointestinal Stromal Tumors
NCTID: NCT00009698
Title: Interleukin-2 in Treating Children Who Have Undergone Bone Marrow Transplantation for Acute Myeloid Leukemia Study Summary: RATIONALE: Interleukin-2 may stimulate a person’s white blood cells to kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of interleukin-2 in treating children who have undergone bone marrow transplantation for acute myeloid leukemia. Sponsor: Children’s Oncology Group Intervention: aldesleukin Start Date: 1998-03 Last Updated: 2013-06-28 Number of Patients: 1 Recruitment Status: COMPLETED Condition: Leukemia
NCTID: NCT04472598
Title: Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis Study Summary: Myelofibrosis is a type of bone marrow cancer that usually develops slowly and disrupts body’s normal production of blood cells. It causes bone marrow scarring, leading to severe anemia that can cause weakness and fatigue. It can also cause a low number of blood-clotting cells called platelets, which increases risk of bleeding. Myelofibrosis often causes an enlarged spleen. The purpose of this study is to see if a combination of navitoclax and ruxolitinib is more effective and safe in assessment of change in spleen volume when compared to ruxolitinib in participants with myelofibrosis. Navitoclax is an investigational drug for the treatment of myelofibrosis. Participants in this study are divided into two groups, called treatment arms. Each group receives a different treatment. Adult participants with a diagnosis of myelofibrosis will be enrolled. Around 230 participants will be enrolled in approximately 190 sites worldwide. Participants will receive oral navitoclax tablet with oral ruxolitinib tablet or oral ruxolitinib tablet with oral placebo (no active drug) tablet and treatment may continue untill the participant cannot tolerate the study drug, or benefit is not achieved, or other reasons which qualify for discontinuation of the study drug. There may be a higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the course of the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, magnetic resonance imaging (MRI) or computed tomography (CT) scan, bone marrow tests, checking for side effects, and completing questionnaires. Sponsor: AbbVie Intervention: Navitoclax Start Date: 2020-09-29 Last Updated: 2023-04-27 Number of Patients: 252 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Myelofibrosis (MF)
NCTID: NCT00002944
Title: Combination Chemotherapy in Treating Children With Progressive Brain Tumors Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: This randomized phase III trial is studying two different combination chemotherapy regimens and comparing how well they work in treating children with low-grade astrocytomas or other residual tumors of the brain. Sponsor: Children’s Oncology Group Intervention: carboplatin Start Date: 1997-04 Last Updated: 2013-09-09 Number of Patients: 428 Recruitment Status: COMPLETED Condition: Brain Tumors
NCTID: NCT02322281
Title: TIGER-3: Open Label, Multicenter Study of Rociletinib (CO-1686) Mono Therapy Versus Single-agent Cytotoxic Chemotherapy in Patients With Mutant EGFR NSCLC Who Have Failed at Least One Previous EGFR-Directed TKI and Platinum-doublet Chemotherapy Study Summary: The purpose of this study is to compare the anti-tumor efficacy of oral single-agent rociletinib, as measured by investigator assessment of the PFS, with that of single-agent cytotoxic chemotherapy in patients with EGFR-mutated, advanced/metastatic NSCLC after failure of at least 1 previous EGFR-directed TKI and at least 1 line of platinum-containing doublet chemotherapy. Sponsor: Clovis Oncology, Inc. Intervention: Rociletinib Start Date: 2015-02 Last Updated: 2019-08-14 Number of Patients: 149 Recruitment Status: TERMINATED Condition: Non-small Cell Lung Cancer
NCTID: NCT04143711
Title: Study of DF1001 in Patients With Advanced Solid Tumors Study Summary: DF1001-001 is a study of a new molecule that targets natural killer (NK) cells and T-cell activation signals to specific receptors on cancer cells. The study will occur in two phases. The first phase will be a dose escalation phase, enrolling patients with various types of solid tumors that express human epidermal growth factor receptor 2 (HER2). Two combination therapy cohorts will be opened for enrollment, DF1001 + nivolumab and DF1001 + Nab paclitaxel. The second phase will include a dose expansion using the best dose selected from the first phase of the study. Multiple cohorts will be opened with eligible patients having either selected solid tumors, or solid tumors expressing high levels of HER2. Sponsor: Dragonfly Therapeutics Intervention: DF1001 Start Date: 2019-11-11 Last Updated: 2022-12-06 Number of Patients: 490 Recruitment Status: RECRUITING Condition: Solid Tumor, Adult
NCTID: NCT00003811
Title: Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Study Summary: RATIONALE: Chemotherapy drugs use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs such as amifostine may protect normal cells from the side effects of chemotherapy. PURPOSE: Phase I trial to study the effectiveness of high-dose cisplatin, etoposide, and bleomycin plus amifostine in treating children who have malignant germ cell tumors. Sponsor: Children’s Oncology Group Intervention: bleomycin sulfate Start Date: 2000-04 Last Updated: 2013-07-04 Number of Patients: 27 Recruitment Status: COMPLETED Condition: Childhood Germ Cell Tumor
NCTID: NCT00002611
Title: Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. It is not yet known whether combination chemotherapy alone or combination chemotherapy plus radiation therapy is more effective for childhood kidney cancer. PURPOSE: Phase III trial to compare the effectiveness of combination chemotherapy with or without radiation therapy in treating children who have kidney cancer. Sponsor: Children’s Oncology Group Intervention: dactinomycin Start Date: 1995-07 Last Updated: 2021-02-25 Number of Patients: 3031 Recruitment Status: COMPLETED Condition: Kidney Cancer
NCTID: NCT00003234
Title: Vinorelbine in Treating Children With Recurrent or Refractory Cancers Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of vinorelbine in treating children with recurrent or refractory cancer. Sponsor: Children’s Oncology Group Intervention: vinorelbine tartrate Start Date: 1998-05 Last Updated: 2014-07-28 Number of Patients: 50 Recruitment Status: COMPLETED Condition: Brain and Central Nervous System Tumors
NCTID: NCT02737501
Title: ALTA-1L Study: A Study of Brigatinib Versus Crizotinib in Anaplastic Lymphoma Kinase Positive (ALK+) Advanced Non-small Cell Lung Cancer (NSCLC) Participants Study Summary: The purpose of the study is to compare the efficacy of brigatinib to that of crizotinib in ALK+ locally advanced or metastatic non-small cell lung cancer (NSCLC) participants naive to ALK inhibitors, as evidenced by progression-free survival (PFS). Sponsor: Ariad Pharmaceuticals Intervention: Brigatinib Start Date: 2016-05-26 Last Updated: 2021-08-20 Number of Patients: 275 Recruitment Status: COMPLETED Condition: Non-small Cell Lung Cancer
NCTID: NCT00006734
Title: Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing’s Sarcoma or Neuroectodermal Tumor Study Summary: RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which chemotherapy regimen combined with radiation therapy and/or surgery is more effective in treating Ewing’s sarcoma or primitive neuroectodermal tumor. PURPOSE: Randomized phase III trial to compare the effectiveness of different chemotherapy regimens combined with radiation therapy and/or surgery in treating patients who have Ewing’s sarcoma or primitive neuroectodermal tumor. Sponsor: Children’s Oncology Group Intervention: filgrastim Start Date: 2001-05 Last Updated: 2023-08-03 Number of Patients: 587 Recruitment Status: COMPLETED Condition: Sarcoma
NCTID: NCT04303780
Title: Study to Compare AMG 510 “Proposed INN Sotorasib” With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200). Study Summary: A Phase 3 Study to Compare AMG 510 with Docetaxel in Non Small Cell Lung Cancer (NSCLC) subjects with KRAS p. G12c mutation Sponsor: Amgen Intervention: AMG 510 Start Date: 2020-06-04 Last Updated: 2023-10-23 Number of Patients: 345 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: KRAS p, G12c Mutated /Advanced Metastatic NSCLC
NCTID: NCT01849874
Title: A Study of MEK162 vs. Physician’s Choice Chemotherapy in Patients With Low-grade Serous Ovarian, Fallopian Tube or Peritoneal Cancer Study Summary: The MILO Study (MEK Inhibitor in Low-grade Serous Ovarian Cancer) is a Phase 3 study during which patients with recurrent or persistent low-grade serous (LGS) carcinomas of the ovary, fallopian tube or primary peritoneum will receive either investigational study drug MEK162 or a chemotherapy chosen by the physician (liposomal doxorubicin, paclitaxel or topotecan). Patients will be followed to compare the effectiveness of the study drug to that of the selected chemotherapies. Patients may be eligible to crossover from physician’s choice chemotherapy to MEK162 if they meet certain inclusion criteria including centrally confirmed disease progression. Approximately 360 patients from North America, Europe and Australia will be enrolled in this study. Sponsor: Pfizer Intervention: MEK162, MEK inhibitor; oral Start Date: 2013-06-27 Last Updated: 2023-10-30 Number of Patients: 341 Recruitment Status: TERMINATED Condition: Low-grade Serous Ovarian Cancer
NCTID: NCT00006024
Title: Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant Glioma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of temozolomide plus lomustine followed by radiation therapy in treating patients who have high-grade malignant glioma. Sponsor: Children’s Oncology Group Intervention: lomustine Start Date: 2000-11 Last Updated: 2014-02-13 Number of Patients: 32 Recruitment Status: COMPLETED Condition: Brain Tumor
NCTID: NCT04623541
Title: Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter’s Syndrome Study Summary: The study is a global, multi-center safety and efficacy trial of epcoritamab, an antibody also known as EPKINLY™ and GEN3013 (DuoBody®-CD3xCD20). Epcoritamab will either be studied as: * Monotherapy, or * Combination therapy: ** epcoritamab + venetoclax ** epcoritamab + lenalidomide ** epcoritamab + R-CHOP (i.e., rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisone). The study includes patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL)/small lymphocytic lymphoma (SLL) and patients with Richter’s Syndrome (RS). Study participants with R/R CLL/SLL are treated either with epcoritamab as monotherapy or epcoritamab + venetoclax. Study participants with RS are treated either with epcoritamab as monotherapy or epcoritamab + lenalidomide or epcoritamab + R-CHOP. The trial consists of two parts, a dose-escalation phase (phase Ib) and an expansion phase (phase II). Patients with RS are only included in the expansion phase. Sponsor: Genmab Intervention: Epcoritamab Start Date: 2020-11-25 Last Updated: 2023-11-15 Number of Patients: 184 Recruitment Status: RECRUITING Condition: Relapsed/Refractory Chronic Lymphocytic Leukemia
NCTID: NCT00002941
Title: Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Recurrent or Refractory Hodgkin’s or Non-Hodgkin’s Lymphoma Study Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy and kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy followed by peripheral stem cell transplantation in treating children who have recurrent or refractory Hodgkin’s lymphoma or non-Hodgkin’s lymphoma. Sponsor: Children’s Oncology Group Intervention: carmustine Start Date: 1998-04 Last Updated: 2014-08-01 Number of Patients: 69 Recruitment Status: COMPLETED Condition: Lymphoma
NCTID: NCT03748641
Title: A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer Study Summary: The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate plus prednisone (AAP) compared to AAP and placebo. Sponsor: Janssen Research & Development, LLC Intervention: Niraparib Start Date: 2019-01-25 Last Updated: 2023-11-13 Number of Patients: 765 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Castration-Resistant Prostatic Cancer
NCTID: NCT05605899
Title: Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma Study Summary: The goal of this clinical study is to compare the study drug, axicabtagene ciloleucel, versus standard of care (SOC) in first-line therapy in participants with high-risk large B-cell lymphoma. Sponsor: Kite, A Gilead Company Intervention: Axicabtagene Ciloleucel Start Date: 2023-02-10 Last Updated: 2023-11-18 Number of Patients: 300 Recruitment Status: RECRUITING Condition: High-risk Large B-cell Lymphoma (LBCL)
NCTID: NCT05382299
Title: Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician’s Choice in Patients With Previously Untreated Metastatic Triple-Negative Breast Cancer Study Summary: The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) versus treatment of physician’s choice (TPC) in participants with previously untreated, locally advanced, inoperable or metastatic triple-negative breast cancer whose tumors do not express programmed cell death ligand 1 (PD-L1) or in participants previously treated with anti-programmed cell death (ligand or protein) 1 (Anti-PD-(L)1) Agents in the early setting whose tumors do express PD-L1. Sponsor: Gilead Sciences Intervention: Sacituzumab Govitecan-hziy Start Date: 2022-07-20 Last Updated: 2023-11-15 Number of Patients: 540 Recruitment Status: RECRUITING Condition: Triple Negative Breast Cancer
NCTID: NCT03616470
Title: Study to Determine the Efficacy of Uproleselan (GMI-1271) in Combination With Chemotherapy to Treat Relapsed/Refractory Acute Myeloid Leukemia Study Summary: This study will evaluate the efficacy of uproleselan (GMI-1271), a specific E-selectin antagonist, in combination with chemotherapy to treat relapsed/refractory AML, compared to chemotherapy alone. The safety of uproleselan when given with chemotherapy will also be investigated in patients with relapsed/refractory AML Sponsor: GlycoMimetics Incorporated Intervention: Uproleselan Start Date: 2018-10-15 Last Updated: 2023-07-25 Number of Patients: 388 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Acute Myeloid Leukemia
NCTID: NCT01801111
Title: A Study of Alectinib (RO5424802) in Participants With Non-Small Cell Lung Cancer Who Have Anaplastic Lymphoma Kinase (ALK) Mutation and Failed Crizotinib Treatment Study Summary: This open-label, non-randomized, multicenter, Phase 1/2 study will evaluate the safety and efficacy of alectinib in participants with non-small cell lung cancer who have ALK mutation and failed crizotinib treatment. In Part 1, cohorts of participants will receive escalating doses of alectinib orally twice daily. In Part 2, participants will receive the recommended phase 2 dose (RP2D) of alectinib as determined in Part 1. Treatment will continue in Part 1 and Part 2 on the same dose until disease progression. In Part 3, following disease progression, participants without epidermal growth factor receptor (EGFR) mutation will be offered continued treatment with alectinib, participants with EGFR mutations will be offered a combination of alectinib and erlotinib. Sponsor: Hoffmann-La Roche Intervention: Erlotinib Start Date: 2013-06-20 Last Updated: 2018-11-02 Number of Patients: 138 Recruitment Status: COMPLETED Condition: Non-Small-Cell Lung Carcinoma
NCTID: NCT02631070
Title: A Study of Luspatercept (ACE-536) to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes Study Summary: The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is a Phase 3, double-blind, randomized, placebo-controlled, multicenter study to determine the efficacy and safety of luspatercept (ACE-536) versus placebo in participants with anemia due to the Revised International Prognostic Scoring System (IPSS-R) very low, low, or intermediate MDS with ring sideroblasts who require red blood cell (RBC) transfusions. Sponsor: Celgene Intervention: Luspatercept Start Date: 2016-02-09 Last Updated: 2021-12-17 Number of Patients: 229 Recruitment Status: COMPLETED Condition: Myelodysplastic Syndromes
NCTID: NCT04313881
Title: Magrolimab + Azacitidine Versus Azacitidine + Placebo in Untreated Participants With Myelodysplastic Syndrome (MDS) Study Summary: The primary objective of this study is to evaluate the efficacy of magrolimab in combination with azacitidine compared to that of azacitidine plus placebo in previously untreated participants with intermediate/high/very high risk myelodysplastic syndrome (MDS) by Revised International Prognostic Scoring System (IPSS-R) as measured by complete remission (CR) and overall survival (OS). Sponsor: Gilead Sciences Intervention: Magrolimab Start Date: 2020-09-09 Last Updated: 2023-09-25 Number of Patients: 539 Recruitment Status: TERMINATED Condition: Myelodysplastic Syndromes
NCTID: NCT02678299
Title: Phase 1/2 Study of the Combination of Pixantrone, Etoposide, Bendamustine and, in CD20 Positive Tumors, Rituximab in Patients With Relapsed Aggressive Non-Hodgkin Lymphomas of B- or T-cell Phenotype - the P[R]EBEN Study Study Summary: This is a phase 1/2 open label study to assess the safety and efficacy of pixantrone in combination with bendamustine, etoposide and , for CD20 positive B-cell lymphomas, rituximab (P<math display="block">R</math>EBEN), in patients with relapsed aNHL of B- or T-cell phenotype. Sponsor: University of Aarhus Intervention: PREBEN Start Date: 2016-02 Last Updated: 2022-08-04 Number of Patients: 60 Recruitment Status: ACTIVE_NOT_RECRUITING Condition: Malignant Lymphoma
