BRAF

BRAF is a gene that encodes a protein called B-Raf, which is part of the MAPK/ERK signaling pathway involved in regulating cell growth and division. Mutations in the BRAF gene, particularly the V600E mutation, are commonly found in various cancers, including melanoma, colorectal, and thyroid cancers. These mutations lead to the continuous activation of the B-Raf protein, driving uncontrolled cell proliferation and tumour growth. Detecting BRAF mutations in cancer patients is critical for guiding targeted therapy decisions, as specific inhibitors can effectively block the aberrant B-Raf activity. Understanding BRAF mutations allows for personalized treatment approaches, improving the effectiveness of therapies and offering better outcomes for patients with BRAF-mutant cancers.